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Normalization is a required preprocessing step, especially for deep learning and convolutional neural networks, such that the network becomes unbiased towards the different features. However, in medical images, the whole intensity normalization may lead to reduced sensitivity for relatively important features. The objective of this master thesis is to study the state-of-the-art normalization techniques used in 2D images, investigate the applicability of such techniques in 3D medical images, and apply them either as a preprocessing step or as feature-wise batch normalization during the model training.
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