| Abstract
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<p><strong>Motivation:</str … <p><strong>Motivation:</strong> Understanding the substrate specificity of HIV-1 protease is important when designing effective HIV-1 protease inhibitors. Furthermore, characterizing and predicting the cleavage profile of HIV-1 protease is essential to generate and test hypotheses of how HIV-1 affects proteins of the human host. Currently available tools for predicting cleavage by HIV-1 protease can be improved.</p><p><strong>Results:</strong> The linear support vector machine with orthogonal encod-ing is shown to be the best predictor for HIV-1 protease cleavage. It is considerably better than current publicly available predictor ser-vices. It is also found that schemes using physicochemical proper-ties do not improve over the standard orthogonal encoding scheme. Some issues with the currently available data are discussed.</p><p><strong>Availability:</strong> The data sets used, which are the most important part, are available at the UCI Machine Learning Repository. The tools used are all standard and easily available. © 2014 The Author.</p>ly available. © 2014 The Author.</p>
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| Author
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Thorsteinn Rögnvaldsson +
, Liwen You +
, Daniel Garwicz +
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| DOI
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http://dx.doi.org/10.1093/bioinformatics/btu810 +
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| Diva
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http://hh.diva-portal.org/smash/record.jsf?searchId=1&pid=diva2:768706
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| EndPage
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1210 +
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| Issue
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8 +
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| Journal
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Bioinformatics +
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| PublicationType
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Journal Paper +
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| Publisher
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Oxford University Press +
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| StartPage
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1204 +
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| Title
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State of the art prediction of HIV-1 protease cleavage sites +
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| Volume
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31 +
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| Year
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2015 +
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| Has queryThis property is a special property in this wiki.
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Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
, Publications:State of the art prediction of HIV-1 protease cleavage sites +
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| Categories |
Publication +
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| Modification dateThis property is a special property in this wiki.
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30 September 2016 20:40:51 +
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