| Abstract
|
<p>HIV-1 protease has a broad and co … <p>HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.</p>spects of these are highlighted.</p>
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| Author
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Thorsteinn Rögnvaldsson +
, Liwen You +
, Daniel Garwicz +
|
| DOI
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http://dx.doi.org/10.1586/14737159.7.4.435 +
|
| Diva
|
http://hh.diva-portal.org/smash/record.jsf?searchId=1&pid=diva2:239220
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| EndPage
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451 +
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| Issue
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4 +
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| Journal
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Expert Review of Molecular Diagnostics +
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| PublicationType
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Journal Paper +
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| Publisher
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Expert Reviews Ltd +
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| StartPage
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435 +
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| Title
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Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
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| Volume
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7 +
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| Year
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2007 +
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| Has queryThis property is a special property in this wiki.
|
Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
, Publications:Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview +
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| Categories |
Publication +
|
| Modification dateThis property is a special property in this wiki.
|
30 September 2016 20:41:53 +
|
